Publications
- Immunogenicity of mRNA vs. BBV152 vaccine boosters against Omicron subvariants: Final results from Phase B of the PRIBIVAC study, a randomized clinical trial
Poh XY, Torres-Ruesta A, Yoong T, Wong N, Tan CW, Rouers A, Chavatte JM, Goh YS, Rao S, Chia PY, Ong SWX, Lee TH, Sadarangani SP, Lin RJH, Neo V, Kam IKJ, Huang Y, Hor PX, Loh CY; PRIBIVAC study group; Yeoh AY, Lim DRX, Chia W, Ren EC, Lin RTP, Fong SW, Renia L, Lye DC, Wang LF, Ng LFP, Young BE
Vaccine. 2024 Nov 14;42(25):126275. doi: 10.1016/j.vaccine.2024.126275. Epub 2024 Sep 5. PMID: 39241318.
- First SARS-CoV-2 Omicron infection as an effective immune booster among mRNA vaccinated individuals: final results from the first phase of the PRIBIVAC randomised clinical trial
Poh XY, Lee IR, Tan CW, Chavatte JM, Fong SW, Goh YS, Rouers A, Wong N, Torres-Ruesta A, Mah SYY, Yeoh AYY, Gandhi M, Rahman N, Chin YQ, Lim JJ, Yoong TJK, Rao S, Chia PY, Ong SWX, Lee TH, Sadarangani SP, Lin RJH, Lim DRX, Chia W, Renia L, Ren EC, Lin RTP, Lye DC, Wang LF, Ng LFP, Young BE
EBioMedicine. 2024 Sep;107:105275. doi: 10.1016/j.ebiom.2024.105275. Epub 2024 Aug 12. PMID: 39137572; PMCID: PMC11367514.
- Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave
Goh YS, Fong SW, Tay MZ, Rouers A, Chang ZW, Chavatte JM, Hor PX, Loh CY, Huang Y, Tan YJ, Wang B, Ngoh EZX, Mohd Salleh SN, Lee RTC, Lim G; NCID Study Group; COVID-Study Group; Maurer-Stroh S, Wang CI, Leo YS, Lin RTP, Lam MC, Lye DC, Young BE, Ng LFP, Renia L
Sci Rep. 2023 Nov 7;13(1):19331. doi: 10.1038/s41598-023-46800-x. Erratum in: Sci Rep. 2024 Jan 17;14(1):1492. PMID: 37935965; PMCID: PMC10630438.
- Third dose of BNT162b2 improves immune response in liver transplant recipients to ancestral strain but not Omicron BA.1 and XBB
Chang ZW*, Goh YS*, Rouers A*, Fong SW*, Tay MZ*, Chavatte JM, Hor PX, Loh CY, Huang Y, Tan YJ, Neo V, Kam IKJ, Yeo NK, Tan EX, Huang D, Wang B, Salleh SNM, Ngoh EZX, Wang CI, Leo YS, Lin RTP, Lye DCB, Young BE, Muthiah M, Ng LFP, Rénia L
Front Immunol. 2023 Jul 3;14:1206016. doi: 10.3389/fimmu.2023.1206016. PMID: 37465685; PMCID: PMC10350672.
*1st co-author
- A nonstructural protein 1 capture enzyme-linked immunosorbent assay specific for dengue viruses
Lim PY, Ramapraba A, Loy T, Rouers A, Thein TL, Leo YS, Burton DR, Fink K, Wang CI
PLoS One. 2023 May 18;18(5):e0285878. doi: 10.1371/journal.pone.0285878. PMID: 37200264; PMCID: PMC10194908.
- Heterologous mRNA vaccine boosters induce a stronger and longer-lasting antibody response against Omicron XBB variant
Tay MZ, Goh YS, Fong SW, Chang ZW, Rouers A, Wong N, Torres-Ruesta A, Huang Y, Selvam SK, Hor PX, Loh CY, Wang B, Mohd Salleh SN, Ngoh EZX, Lee RTC, Neo V, Kam IKJ, Poh XY, Rao S, Chia PY, Ong SWX, Lee TH, Lim C, Teo J; NCID Study Group; PRIBIVAC Cohort Study Group; Maurer-Stroh S, Wang CI, Leo YS, Lin RTP, Lye DC, Young BE, Ng LFP, Renia L
Lancet Reg Health West Pac. 2023 Apr;33:100732. doi: 10.1016/j.lanwpc.2023.100732. Epub 2023 Mar 7. PMID: 37125085; PMCID: PMC9988436.
- B-cell ELISpot assay to analyze human memory B cell and plasmablast responses specific to SARS-CoV-2 receptor-binding domain
Rouers A, Tay MZ, Ng LFP, Renia L.
STAR Protoc. 2023 Feb 9;4(1):102130. doi: 10.1016/j.xpro.2023.102130. Epub ahead of print. PMID: 36853725; PMCID: PMC9910018.
- Waning of specific antibodies against Delta and Omicron variants five months after a third dose of BNT162b2 SARS-CoV-2 vaccine in elderly individuals
Goh YS, Rouers A, Fong SW, Zhuo NZ, Hor PX, Loh CY, Huang Y, Neo VK, Kam IKJ, Wang B, Ngoh EZX, Salleh SNM, Lee RTC, Pada S, Sun LJ, Ong DLS, Somani J, Lee ES; NCID Study Group; COVID-19 Study Group; Maurer-Stroh S, Wang CI, Leo YS, Ren EC, Lye DC, Young BE, Ng LFP, Renia L
Front Immunol. 2022 Nov 14;13:1031852. doi: 10.3389/fimmu.2022.1031852. PMID: 36451833; PMCID: PMC9704817.
- Efficient recall of SARS-CoV-2 variant-reactive B cells and T responses in the elderly upon heterologous mRNA vaccines as boosters
Rouers A*, Wong N*, Goh YS, Torres-Ruesta A, Tay MZ, Chang ZW, Fong SW, Neo V, Kam IKJ, Yeo NK, Huang Y, Loh CY, Hor PX, Wong JXE, Tan YJ; COVID-19 Study Group, Macary PA, Qian X, Bei W, Ngoh EZX, Salleh SNM, Wang CI, Poh XY, Rao S, Chia PY, Ong SWX, Lee TH, Lin RJH, Lim C, Teo J, Ren EC, Lye DC, Young BE, Ng LFP, Renia L
J Med Virol. 2023 Jan;95(1):e28258. doi: 10.1002/jmv.28258. Epub 2022 Nov 16. PMID: 36305052; PMCID: PMC9874655.
*1st co-author
- A Unique CD27-IgD- B Cell Population in the Sputum of Severe Eosinophilic Asthma Associated with Airway Autoimmunity
Tan NS, Mukherjee M, Lim SY, Rouers A, Hwang YY, Thiam CH, Tan WSD, Liao W, Wong WSF, Liew MF, Nair P, Larbi A, Wang Y, Fink K, Angeli V, Lim HF
Am J Respir Cell Mol Biol. 2022 Oct;67(4):506-511. doi: 10.1165/rcmb.2022-0137LE. PMID: 36178857.
- Heterologous booster vaccination with CoronaVac following prime vaccination with mRNA vaccine
Goh YS, Fong SW, Rouers A, Chang ZW, Tay MZ, Chavatte JM, Zhuo NZ, Hor PX, Loh CY, Huang Y, Wong JXE, Tan YJ, Lim DRX, Wang B, Ngoh EZX, Salleh SNM, Lee RTC, Pada S, Sun LJ, Ong DLS, Somani J, Lee ES; NCID Study Group; COVID‐19 Study Group, Maurer-Stroh S, Wang CI, Leo YS, Lin RT, Ren EC, Lye DC, Young BE, Lim PL, Ng LF, Renia L
Clin Transl Immunology. 2022 Aug 23;11(8):e1403. doi: 10.1002/cti2.1403. PMID: 36016852; PMCID: PMC9398778.
- Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose
Renia L, Goh YS*, Rouers A*, Le Bert N*, Chia WN*, Chavatte JM*, Fong SW*, Chang ZW*, Zhuo NZ*, Tay MZ*, Chan YH, Tan CW, Yeo NK, Amrun SN, Huang Y, Wong JXE, Hor PX, Loh CY, Wang B, Ngoh EZX, Salleh SNM, Carissimo G, Dowla S, Lim AJ, Zhang J, Lim JME, Wang CI, Ding Y, Pada S, Sun LJ, Somani J, Lee ES, Ong DLS; SCOPE Cohort Study Group, Leo YS, MacAry PA, Lin RTP, Wang LF, Ren EC, Lye DC, Bertoletti A, Young BE, Ng LFP
Nat Commun. 2022 Aug 8;13(1):4615. doi: 10.1038/s41467-022-32312-1. PMID: 35941158; PMCID: PMC9358634.
*2nd co-author
- Decreased memory B cells frequencies in COVID-19 Delta variant vaccine breakthrough infection
Tay MZ*, Rouers A*, Fong SW, Goh YS, Chan YH, Chang ZW, Xu W, Tan CW, Chia WN, Torres-Ruesta A, Amrun SN, Huang Y, Hor PX, Loh CY, Yeo NK, Wang B, Ngoh EZX, Salleh SNM, Chavatte JM, Lim AJ, Maurer-Stroh S, Wang LF, Lin RT, Wang CI, Tan SY, Young BE, Leo YS, Lye DC, Renia L, Ng LFP
EMBO Mol Med. 2022 Jan 6:e15227. doi: 10.15252/emmm.202115227. Epub ahead of print. PMID: 34994081
*1st co-author
- Resistance of SARS-CoV-2 Delta variant to neutralization by BNT162b2-elicited antibodies in Asians
Wang B, Goh YS, Fong SW, Young BE, Ngoh EZX, Chavatte JM, Salleh SNM, Yeo NK, Amrun SN, Hor PX, Loh CY, Lee CY, Chan YH, Chang ZW, Tay MZ, Rouers A, Torres-Ruesta A, Carissimo G, Soh MK, Lee RTC, Xu Y, Pada S, Lin RTP, Leo YS, Lye DC, Maurer-Stroh S, Ng LFP, Renia L, Wang CI
Lancet Reg Health West Pac. 2021 Oct;15:100276. doi: 10.1016/j.lanwpc.2021.100276. Epub 2021 Sep 20. PMID: 34568853; PMCID: PMC8450274
- CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function
Rouers A*, Appanna R*, Chevrier M, Lum J, Lau MC, Tan L, Loy T, Tay A, Sethi R, Sathiakumar D, Kaur K, Böhme J, Leo YS, Renia L, Howland SW, Singhal A, Chen J, Fink K
iScience. 2021 Apr 29;24(5):102482. doi: 10.1016/j.isci.2021.102482. PMID: 34113823; PMCID: PMC8169951
*1st co-author
- Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection
Rouers A*, Chng MHY*, Lee B, Rajapakse MP, Kaur K, Toh YX, Sathiakumar D, Loy T, Thein TL, Lim VWX, Singhal A, Yeo TW, Leo YS, Vora KA, Casimiro D, Lim B, Tucker-Kellogg L, Rivino L, Newell EW, Fink K
Cell Rep Med. 2021 May 18;2(5):100278. doi: 10.1016/j.xcrm.2021.100278. PMID: 34095880; PMCID: PMC8149372
*1st co-author
- Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell Fates
Chng MHY, Lim MQ, Rouers A, Becht E, Lee B, MacAry PA, Lye DC, Leo YS, Chen J, Fink K, Rivino L, Newell EW
Immunity. 2019 Dec 17;51(6):1119-1135.e5. doi: 10.1016/j.immuni.2019.10.007. Epub 2019 Nov 19. PMID: 31757672
- The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability
Ronin E, Lubrano di Ricco M, Vallion R, Divoux J, Kwon HK, Grégoire S, Collares D, Rouers A, Baud V, Benoist C, Salomon BL
Front Immunol. 2019 Oct 30;10:2487. doi: 10.3389/fimmu.2019.02487. PMID: 31749798; PMCID: PMC6842949
- HIV-Specific B Cell Frequency Correlates with Neutralization Breadth in Patients Naturally Controlling HIV-Infection
Rouers A*, Klingler J*, Su B, Samri A, Laumond G, Even S, Avettand-Fenoel V, Richetta C, Paul N, Boufassa F, Hocqueloux L, Mouquet H, Rouzioux C, Lambotte O, Autran B, Graff-Dubois S, Moog C, Moris A; ANRS CO21 Cohort
EBioMedicine. 2017 Jul;21:158-169. doi: 10.1016/j.ebiom.2017.05.029. Epub 2017 May 31. PMID: 28615147; PMCID: PMC5514383
*1st co-author
- Triggering of TLR-3, -4, NOD2, and DC-SIGN reduces viral replication and increases T-cell activation capacity of HIV-infected human dendritic cells
Cardinaud S, Urrutia A, Rouers A, Coulon PG, Kervevan J, Richetta C, Bet A, Maze EA, Larsen M, Iglesias MC, Appay V, Graff-Dubois S, Moris A
Eur J Immunol. 2017 May;47(5):818-829. doi: 10.1002/eji.201646603. Epub 2017 Apr 13. PMID: 28266028
- HIV-Infected Dendritic Cells Present Endogenous MHC Class II-Restricted Antigens to HIV-Specific CD4+ T Cells
Coulon PG, Richetta C*, Rouers A*, Blanchet FP, Urrutia A, Guerbois M, Piguet V, Theodorou I, Bet A, Schwartz O, Tangy F, Graff-Dubois S, Cardinaud S, Moris A
J Immunol. 2016 Jul 15;197(2):517-32. doi: 10.4049/jimmunol.1600286. Epub 2016 Jun 10. PMID: 27288536
*2nd co-author
- B Cells Loaded with Synthetic Particulate Antigens: A Versatile Platform To Generate Antigen-Specific Helper T Cells for Cell Therapy
Sicard A, Koenig A, Graff-Dubois S, Dussurgey S, Rouers A, Dubois V, Blanc P, Chartoire D, Errazuriz-Cerda E, Paidassi H, Taillardet M, Morelon E, Moris A, Defrance T, Thaunat O
Nano Lett. 2016 Jan 13;16(1):297-308. doi: 10.1021/acs.nanolett.5b03801. Epub 2015 Dec 16. PMID: 26650819
- HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation
Colineau L*, Rouers A*, Yamamoto T, Xu Y, Urrutia A, Pham HP, Cardinaud S, Samri A, Dorgham K, Coulon PG, Cheynier R, Hosmalin A, Oksenhendler E, Six A, Kelleher AD, Zaunders J, Koup RA, Autran B, Moris A, Graff-Dubois S
PLoS One. 2015 Oct 26;10(10):e0140978. doi: 10.1371/journal.pone.0140978. PMID: 26501424; PMCID: PMC4621058
*1st co-author
- Effector T cells boost regulatory T cell expansion by IL-2, TNF, OX40, and plasmacytoid dendritic cells depending on the immune context
Baeyens A, Saadoun D, Billiard F, Rouers A, Grégoire S, Zaragoza B, Grinberg-Bleyer Y, Marodon G, Piaggio E, Salomon BL
J Immunol. 2015 Feb 1;194(3):999-1010. doi: 10.4049/jimmunol.1400504. Epub 2014 Dec 29. PMID: 25548233
COVID-19 Study Group
- Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults
Ho VWT, Boon LH, Cui J, Juequn Z, Shunmuganathan B, Gupta R, Tan NYJ, Qian X, Purushotorman K; SCOPE Cohort Study Group; Fong SW, Renia L, Ng LFP, Angeli V, Chen J, Kennedy BK, Ong CWM, Macary PA
Aging Cell. 2024 Apr;23(4):e14099. doi: 10.1111/acel.14099. Epub 2024 Feb 5. PMID: 38317404; PMCID: PMC11019126.
*contribution in SCOPE Cohort Study Group
- Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2
Gu Y, Shunmuganathan B, Qian X, Gupta R, Tan RSW, Kozma M, Purushotorman K, Murali TM, Tan NYJ, Preiser PR, Lescar J, Nasir H, Somani J, Tambyah PA; SCOPE Cohort Study Group*; Smith KGC, Renia L, Ng LFP, Lye DC, Young BE, MacAry PA
Sci Rep. 2023 Dec 9;13(1):21810. doi: 10.1038/s41598-023-49231-w. PMID: 38071323; PMCID: PMC10710454.
*contribution in SCOPE Cohort Study Group
- Variant-Specific IgA Protects Against Omicron Infection
Goh YS, Fong SW, Hor PX, Loh CY, Wang B, Salleh SNM, Ngoh EZX, Lee RTC, Poh XY, Rao S, Chia PY, Ong SWX, Lee TH, Lim C, Teo J, Pada S, Sun LJ, Ong DLS, Somani J, Lee ES, Maurer-Stroh S, Wang CI, Leo YS, Lye DC, Young BE, Ng LFP, Renia L; NCID Study Group; COVID-19 Cohort Study Group*
J Infect Dis. 2024 Aug 16;230(2):e287-e291. doi: 10.1093/infdis/jiad525. PMID: 37996071; PMCID: PMC11326848.
*contribution in COVID-19 Cohort Study Group
- Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults
Ho VWT, Boon LH, Cui J, Juequn Z, Shunmuganathan B, Gupta R, Tan NYJ, Qian X, Purushotorman K; SCOPE Cohort Study Group*; Fong SW, Renia L, Ng LFP, Angeli V, Chen J, Kennedy BK, Ong CWM, Macary PA
Aging Cell. 2024 Feb 5:e14099. doi: 10.1111/acel.14099. Epub ahead of print. PMID: 38317404.
*contribution in SCOPE Cohort Study Group
- Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2
Gu Y, Shunmuganathan B, Qian X, Gupta R, Tan RSW, Kozma M, Purushotorman K, Murali TM, Tan NYJ, Preiser PR, Lescar J, Nasir H, Somani J, Tambyah PA; SCOPE Cohort Study Group; Smith KGC, Renia L, Ng LFP, Lye DC, Young BE, MacAry PA
Sci Rep. 2023 Dec 9;13(1):21810. doi: 10.1038/s41598-023-49231-w. PMID: 38071323; PMCID: PMC10710454.
*contribution in SCOPE Cohort Study Group
- Variant-specific IgA protects against Omicron infection
Goh YS, Fong SW, Hor PX, Loh CY, Wang B, Salleh SNM, Ngoh EZX, Lee RTC, Poh XY, Rao S, Chia PY, Ong SWX, Lee TH, Lim C, Teo J, Pada S, Sun LJ, Ong DLS, Somani J, Lee ES, Maurer-Stroh S, Wang CI, Leo YS, Lye DC, Young BE, Ng LFP, Renia L; NCID Study Group; COVID-19 Cohort Study Group*
J Infect Dis. 2023 Nov 23:jiad525. doi: 10.1093/infdis/jiad525. Epub ahead of print. PMID: 37996071.
*contribution in COVID-19 Cohort Study Group
Scientific reviews
- Lymphocytes T folliculaires helper et VIH - Unis pour le meilleur et pour le pire [Follicular helper T cells and HIV - United for better and worse]
Rouers A, Jeger-Madiot R, Moris A, Graff-Dubois S
Med Sci (Paris). 2017 Oct;33(10):878-886. French. doi: 10.1051/medsci/20173310020. Epub 2017 Oct 10. PMID: 28994384
- Impact of Chronic HIV/SIV Infection on T Follicular Helper Cell Subsets and Germinal Center Homeostasis
Graff-Dubois S, Rouers A, Moris A
Front Immunol. 2016 Nov 11;7:501. doi: 10.3389/fimmu.2016.00501. PMID: 27891132; PMCID: PMC5105356